Article
Protein structure determination using a combination of comparative modeling and NMR spectroscopy. Application to the response regulator protein, Spo0F.
Journal of medicinal chemistry - 10 Oct 1997
Podlogar B L, Leo G C, McDonnell P A, Loughney D A, Caldwell G W, Barrett J F
Abstract excerpt
A practical combination of comparative modeling and NMR spectroscopy was used to generate a three-dimensional structure of the response regulator protein, Spo0F. The backbone structure obtained compares to the Spo0F Y13S mutant X-ray structure with an rmsd of 2.0 A. We provide results which suggest that structures obtained by this method are suitable for drug discovery. The results of the GRID and DOCK methods as...
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