Tay-Sachs disease and HEXA mutations among Moroccan Jews.

doi:10.1002/(SICI)1098-1004(1997)10:4<295::AID-HUMU5>3.0.CO;2-G

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Article

Tay-Sachs disease and HEXA mutations among Moroccan Jews.

Human mutation - 1 Jan 1997

Kaufman M, Grinshpun-Cohen J, Karpati M, Peleg L, Goldman B, Akstein E, Adam A, Navon R

Abstract excerpt

Moroccan Jewry (N>750,000) is the only non-Ashkenazi Jewish community in which Tay-Sachs disease (TSD) is not extremely rare. Previous studies among Moroccan Jewish TSD families identified three HEXA mutations. In this study, extended to enzyme-defined and new obilgate TSD carriers, we found four...

Topics

Heterozygote
Hexosaminidase A
Humans
Jews
Morocco
Mutation
Tay-Sachs Disease
beta-N-Acetylhexosaminidases

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