Tay-Sachs disease in Moroccan Jews: deletion of a phenylalanine in the alpha-subunit of beta-hexosaminidase.

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Article

Tay-Sachs disease in Moroccan Jews: deletion of a phenylalanine in the alpha-subunit of beta-hexosaminidase.

American journal of human genetics - 1 Feb 1991

Navon R, Proia R L

Abstract excerpt

Tay-Sachs disease is an inherited lysosomal storage disorder caused by defects in the beta-hexosaminidase alpha-subunit gene. The carrier frequency for Tay-Sachs disease is significantly elevated in both the Ashkenazi Jewish and Moroccan Jewish populations but not in other Jewish groups. We have found that the mutations underlying Tay-Sachs disease in Ashkenazi and Moroccan Jews are different. Analysis of a...

Topics

Alleles
Base Sequence
Cells, Cultured
Codon
DNA
Heterozygote
Humans
Jews
Molecular Sequence Data
Morocco
Mutation
Oligonucleotide Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenylalanine

Polymerase Chain Reaction

Precipitin Tests

RNA, Messenger

Tay-Sachs Disease

beta-N-Acetylhexosaminidases

Source

Open in PubMed Open full text

Identifiers

PMID: 1825014
PMCID: PMC1683003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1825014-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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