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Article

Design of thermolabile bacteriophage repressor mutants by comparative molecular modeling.

Nature biotechnology - 1 Oct 1997

Nauta A, van den Burg B, Karsens H, Venema G, Kok J

Abstract excerpt

Comparative molecular modeling was performed with repressor protein Rro of the temperate Lactococcus lactis bacteriophage r1t using the known 3D-structures of related repressors in order to obtain thermolabile derivatives of Rro. Rro residues presumed to stabilize a nonhomologous but structurally conserved hydrophobic pocket, which was shown to be important for thermostability of the Escherichia coli...

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PMID: 9335049
DOI: 10.1038/nbt1097-980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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