Article
The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome.
Human molecular genetics - 1 Nov 1997
Brodsky G, Barnes T, Bleskan J, Becker L, Cox M, Patterson D
Abstract excerpt
Purines are critical for energy metabolism, cell signalling and cell reproduction. Nevertheless, little is known about the regulation of this essential biochemical pathway during mammalian development. In humans, the second, third and fifth steps of de novo purine biosynthesis are catalyzed by a...
Topics
- Animals
- Antibody Specificity
- Brain
- CHO Cells
- Carbon-Nitrogen Ligases
- Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor
- Cerebellum
- Cloning, Molecular
- Cricetinae
- Down Syndrome
- Female
- Gene Expression Regulation, Developmental
- Humans
- Hydroxymethyl and Formyl Transferases