Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome.

Abstract excerpt

BACKGROUND: This study examines the contribution of transmural heterogeneity of transmembrane activity to phenotypic T-wave patterns and the effects of pacing and of sodium channel block under conditions mimicking HERG and SCN5A defects linked to the congenital long-QT syndrome (LQTS). METHODS AND RESULTS: A transmural ECG and transmembrane action potentials from epicardial, M, and endocardial or Purkinje cells...

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