Article
Human neutrophils express GH-N gene transcripts and the pituitary transcription factor Pit-1b.
Endocrinology - 1 Oct 1997
Kooijman R, Berus D, Malur A, Delhase M, Hooghe-Peters E L
Abstract excerpt
Since GH stimulates the development and function of granulocytes, we investigated the expression of GH in granulocyte subsets. By immunocytochemistry, 25 +/- 7% of the human neutrophils were shown to express immunoreactive GH, whereas eosinophils were negative. Reversed transcription (RT)-PCR analysis demonstrated GH mRNA in neutrophils. Restriction analysis revealed that neutrophils express the GH-N gene but not...
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