Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks.

Molecular and cellular biology - 1 Oct 1997

Maser R S, Monsen K J, Nelms B E, Petrini J H

Abstract excerpt

We previously identified a conserved multiprotein complex that includes hMre11 and hRad50. In this study, we used immunofluorescence to investigate the role of this complex in DNA double-strand break (DSB) repair. hMre11 and hRad50 form discrete nuclear foci in response to treatment with DSB-inducing agents but not in response to UV irradiation. hMre11 and hRad50 foci colocalize after treatment with ionizing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Cells, Cultured
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Repair

Share to Fibroblasts

Share to Fungal Proteins

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9315668
DOI: 10.1128/MCB.17.10.6087
PMCID: PMC232458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks.PMID 9315668Read ↗

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.Semantic proximity Read ↗

The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.Semantic proximity Read ↗

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation.Semantic proximity Read ↗

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.Semantic proximity Read ↗

The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA DamageSemantic proximity Read ↗

Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance.Semantic proximity Read ↗

The plant Rad50-Mre11 protein complex.Semantic proximity Read ↗

Mre11-Rad50 oligomerization promotes DNA double-strand break repairSemantic proximity Read ↗

Human RAD50 deficiency: Confirmation of a distinctive phenotype.Semantic proximity Read ↗

The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damageSemantic proximity Read ↗

Physical and Functional Interaction between the XPF/ERCC1 Endonuclease and hRad52Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.