Article
hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks.
Molecular and cellular biology - 1 Oct 1997
Maser R S, Monsen K J, Nelms B E, Petrini J H
Abstract excerpt
We previously identified a conserved multiprotein complex that includes hMre11 and hRad50. In this study, we used immunofluorescence to investigate the role of this complex in DNA double-strand break (DSB) repair. hMre11 and hRad50 form discrete nuclear foci in response to treatment with DSB-indu...
Topics
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- Cell Nucleus
- Cells, Cultured
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Endodeoxyribonucleases
- Enzyme Inhibitors
- Etoposide
- Exodeoxyribonucleases
- Fibroblasts
- Fungal Proteins
- G2 Phase
- Gamma Rays
- Humans
- Mutation