Article
The two opposing activities of adenylyl transferase reside in distinct homologous domains, with intramolecular signal transduction.
The EMBO journal - 15 Sept 1997
Jaggi R, van Heeswijk W C, Westerhoff H V, Ollis D L, Vasudevan S G
Abstract excerpt
Adenylyl transferase (ATase) is the bifunctional effector enzyme in the nitrogen assimilation cascade that controls the activity of glutamine synthetase (GS) in Escherichia coli. This study addresses the question of whether the two antagonistic activities of ATase (adenylylation and deadenylylation) occur at the same or at different active sites. The 945 amino acid residue ATase has been truncated in two ways, so...
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