Article
Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region.
American journal of human genetics - 1 Aug 1997
Arngrímsson R, Hayward C, Nadaud S, Baldursdóttir A, Walker J J, Liston W A, Bjarnadóttir R I, Brock D J, Geirsson R T, Connor J M, Soubrier F
Abstract excerpt
Pregnancy-induced hypertension may be regarded as a manifestation of endothelial-cell dysfunction. The role of the eNOS gene in the development of a familial pregnancy-induced hypertension was evaluated by analysis of linkage among affected sisters and in multiplex families (n = 50). Markers from a 4-cM region encoding the eNOS gene showed distortion from the expected allele sharing among affected sisters (P =...
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