Article
Genetic susceptibility to pre-eclampsia and chromosome 7q36.
Human genetics - 1 Dec 1999
Guo G, Lade J A, Wilton A N, Moses E K, Grehan M, Fu Y, Qiu H, Cooper D W, Brennecke S P
Abstract excerpt
Pre-eclampsia is the most common serious medical disorder of human pregnancy. The human endothelial cell nitric oxide synthase (eNOS) gene is a candidate for pre-eclampsia/eclampsia (PE/E) susceptibility. A linkage study was performed on Australian PE/E families using 25 microsatellite markers from chromosome 7, one of which (eNOS-CA) resides within the eNOS gene. No significant linkage was found for the eNOS-CA...
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