Article
Population genetics and disease susceptibility: characterization of central European haplogroups by mtDNA gene mutations, correlation with D loop variants and association with disease.
Human molecular genetics - 1 Oct 1997
Hofmann S, Jaksch M, Bezold R, Mertens S, Aholt S, Paprotta A, Gerbitz K D
Abstract excerpt
Mitochondrial (mt)DNA haplogroups in a German control group (n = 67) were characterized by screening mitochondrial coding regions encompassing most of the ND, tRNA and cyt b genes. We used a PCR-SSCP screening approach followed by direct sequencing of polymorphic mtDNA fragments. Five major mtDNA...
Topics
- Child
- DNA, Mitochondrial
- Europe
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Germany
- Haplotypes
- Humans
- Infant
- MELAS Syndrome
- Male
- Mutation
- Optic Atrophies, Hereditary
- Sudden Infant Death
- Wolfram Syndrome