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Article

Methylation of novel markers of fragile X alleles is inversely correlated with FMRP expression and FMR1 activation ratio.

Human molecular genetics - 15 Apr 2010

Godler David Eugeny, Tassone Flora, Loesch Danuta Zuzanna, Taylor Annette Kimball, Gehling Freya, Hagerman Randi Jenssen, Burgess Trent, Ganesamoorthy Devika, Hennerich Debbie, Gordon Lavinia, Evans Andrew, Choo K H, Slater Howard Robert

Abstract excerpt

The fragile X syndrome (FXS) is caused by silencing of the fragile X mental retardation gene (FMR1) and the absence of its product, fragile X mental retardation protein (FMRP), resulting from CpG island methylation associated with large CGG repeat expansions (more than 200) termed full mutation (FM). We have identified a number of novel epigenetic markers for FXS using matrix-assisted laser...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20118148
DOI: 10.1093/hmg/ddq037
PMCID: PMC2846165

Genes

FMR1

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