Article
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration.
Science (New York, N.Y.) - 19 Sept 1997
Allikmets R, Shroyer N F, Singh N, Seddon J M, Lewis R A, Bernstein P S, Peiffer A, Zabriskie N A, Li Y, Hutchinson A, Dean M, Lupski J R, Leppert M
Abstract excerpt
Age-related macular degeneration (AMD) is the leading cause of severe central visual impairment among the elderly and is associated both with environmental factors such as smoking and with genetic factors. Here, 167 unrelated AMD patients were screened for alterations in ABCR, a gene that encodes a retinal rod photoreceptor protein and is defective in Stargardt disease, a common hereditary form of macular...
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