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Article

Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8 <sup>+</sup> cytotoxic T lymphocyte responses

16 Sept 1997

Abstract excerpt

The specific mechanisms underlying the varied susceptibility of HIV-infected (HIV+) individuals to opportunistic infections (OI) are still incompletely understood. One hypothesis is that quantitative differences in specific T cell responses to a colonizing organism determine the development of an AIDS-defining OI. We evaluated this hypothesis for herpes simplex virus (HSV) infection, a common OI in HIV+ patients....

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PMID: 9294203
DOI: 10.1073/pnas.94.19.10289

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