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A glycoprotein E deletion mutant of bovine herpesvirus 1 is avirulent in calves

1 Sept 1994

Abstract excerpt

A marker vaccine elicits an antibody response in the host that can be distinguished from the antibody response induced by a wild-type strain. To obtain a bovine herpesvirus 1 (BHV-1) marker vaccine, we constructed a glycoprotein E (gE) deletion mutant. This was obtained by removing the complete gE coding region from the BHV-1 genome. To attenuate the gE deletion mutant further, we also introduced a small deletion...

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PMID: 8077929
DOI: 10.1099/0022-1317-75-9-2311

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