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Article

The Role of Endothelin‐1 in Epidermal Hyperpigmentation and Signaling Mechanisms of Mitogenesis and Melanogenesis

1 Aug 1997

Abstract excerpt

The paracrine linkage of endothelins (ET) between keratinocytes and melanocytes suggested that ETs are intrinsic mediators for human melanocytes in UVB-induced pigmentation. In this study, the role of ET-1 in the epidermal hyperpigmentation was investigated in vivo and in vitro. The addition of 10 nM ET-1 induced a H-7 (10 microM) suppressible-increase in tyrosinase activity in cultured human melanocytes and was...

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Identifiers

PMID: 9263329
DOI: 10.1111/j.1600-0749.1997.tb00488.x

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