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Article

Transient Receptor Potential channels, TRPV1 and TRPA1 in melanocytes synergize UV‐dependent and UV‐independent melanogenesis

7 Aug 2021

Abstract excerpt

BACKGROUND AND PURPOSE: Melanogenesis is essential for pigmentation and deregulated melanogenesis causes pigmentary diseases. Psoralen and ultraviolet A (PUVA) therapy strongly stimulates pigmentation, but the underlying molecular mechanisms are elusive. EXPERIMENTAL APPROACH: Melanin content of cultured human melanocytes was spectrophotometrically measured. Patch-clamp recordings were made in human melanocytes...

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PMID: 34363226
DOI: 10.1111/bph.15643

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