Article
A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits.
Journal of virology - 1 Sept 1997
Hill J M, Garza H H, Su Y H, Meegalla R, Hanna L A, Loutsch J M, Thompson H W, Varnell E D, Bloom D C, Block T M
Abstract excerpt
In this study we used a herpes simplex virus type 1 (HSV-1) deletion mutant to identify a segment of the genome necessary for epinephrine-induced reactivation in the rabbit eye model of herpetic recurrent disease. In HSV-1 latently infected neural tissue, the only abundant viral products are the latency-associated transcripts (LATs). At least one promoter of LAT has been identified, and mutations in the LAT...
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