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Article

The immune response to the HPA‐la antigen: association with HLA‐DRw52a

1 Mar 1991

Abstract excerpt

Antibodies to the HPA-1a antigen can elicit a condition in the new-born known as neonatal alloimmune thrombocytopenia (NAITP). Retrospective and prospective studies have shown that there is a strong correlation between the presence of HLA-DR3, HLA-DRw52 in the mother and the antibody response to HPA-1a. HLA Class II molecules play an important role in the initiation of the immune response and it has been...

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Identifiers

PMID: 9259828
DOI: 10.1111/j.1365-3148.1991.tb00010.x

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Related research

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Research trail→

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The immune response to the HPA‐la antigen: association with HLA‐DRw52aPMID 9259828Read ↗

Alloimmunization to platelet antigen HPA-1a (PIA1) is strongly associated with both HLA-DRB3*0101 and HLA-DQB1*0201.Semantic proximity Read ↗

A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newbornSemantic proximity Read ↗

Prevalence and clinical significance of low‐avidity HPA‐1a antibodies in women exposed to HPA‐1a during pregnancySemantic proximity Read ↗

Neonatal alloimmune thrombocytopenia due to anti-HPA 1a antibodies; the level of maternal antibodies predicts the severity of thrombocytopenia in the newborn.Semantic proximity Read ↗

HLA‐DRB3*01:01 is a predictor of immunization against human platelet antigen‐1a but not of the severity of fetal and neonatal alloimmune thrombocytopeniaSemantic proximity Read ↗

Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.Semantic proximity Read ↗

Foetal and neonatal alloimmune thrombocytopenia - The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome.Semantic proximity Read ↗

Fetoneonatal alloimmune thrombocytopenia (FNAIT): our experience.Semantic proximity Read ↗

HLA-DRB3*01:01 exhibits a dose-dependent impact on HPA-1a antibody levels in HPA-1a–immunized womenSemantic proximity Read ↗

Genetic susceptibility and anti-human platelet antigen 5b alloimmunization role of HLA class II and TAP genes.Semantic proximity Read ↗

The prevalence of HPA-1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR-DQ haplotypes.Semantic proximity Read ↗

BRa (HPA-5b) incompatibility may cause thrombocytopenia in neonates of mothers with immune thrombocytopenic purpura.Semantic proximity Read ↗

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