Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin

Abstract excerpt

Identification of expanding roles for matrix metalloproteinases (MMPs) in complex regulatory processes of tissue remodelling has stimulated the search for genes encoding proteinases with unique functions, regulation and expression patterns. By using a novel cloning strategy, we identified three previously unknown human MMPs, i.e. MMP-21, MMP-26 and MMP-28, in comprehensive gene libraries. The present study is focu...

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• Bone and Dental Protein Studies
• Peptidase Inhibition and Analysis
• Protease and Inhibitor Mechanisms

Identifiers and source

Literature Corpus work

38217120-9ef6-599b-a4df-a956a4313796

DOI

10.1042/bj3560705