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Article

Identification of the five most common cystic fibrosis mutations in single cells using a rapid and specific differential amplification system.

Molecular human reproduction - 1 Mar 1996

Scobie G, Woodroffe B, Fishel S, Kalsheker N

Abstract excerpt

We describe a rapid and specific differential amplification system which can detect five of the most common cystic fibrosis mutations from a single cell. In the first round of the polymerase chain reaction (PCR), regions of exons 4, 10 and 11 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene containing the mutations delta F508, G551D, R553X, G542X and 621+1G > T were co-amplified in a single...

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PMID: 9238680
DOI: 10.1093/molehr/2.3.203

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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