Article
Mutations in the gene encoding thyroid transcription factor-1 (TTF-1) are not a frequent cause of congenital hypothyroidism (CH) with thyroid dysgenesis.
Thyroid : official journal of the American Thyroid Association - 1 Jun 1997
Lapi P, Macchia P E, Chiovato L, Biffali E, Moschini L, Larizza D, Baserga M, Pinchera A, Fenzi G, Di Lauro R
Abstract excerpt
Permanent congenital hypothyroidism (CH) has an incidence of 1/3000-4000 newborns and is among the most frequent cause of mental retardation and neurological alterations in children. In 80% to 85% of cases CH is associated with thyroid dysgenesis. A group of 61 patients with CH (22 with agenesis, 18 with ectopy, 1 with hypoplasia, and 20 cases with CH without thyroid enlargement but not further characterized) and...
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