Article
Sequence analysis of thyroid transcription factor-1 gene reveals absence of mutations in patients with thyroid dysgenesis but presence of polymorphisms in the 5' flanking region and intron.
Endocrine journal - 1 Aug 1998
Hishinuma A, Kuribayashi T, Kanno Y, Onigata K, Nagashima K, Ieiri T
Abstract excerpt
Congenital hypothyroidism is caused by several mechanisms. The most common cause worldwide is iodine deficiency, but in iodine-sufficient regions thyroid dysgenesis is the most common cause of congenital hypothyroidism. In the present study we analyzed the thyroid transcription factor-1 (TTF-1) g...
Topics
- Adolescent
- Adult
- Child
- Child, Preschool
- Female
- Gene Frequency
- Homeodomain Proteins
- Humans
- Infant
- Introns
- Male
- Mutation
- Nuclear Proteins
- Polymorphism, Genetic
- Restriction Mapping
- Sequence Analysis, DNA
- Thyroid Diseases
- Thyroid Nuclear Factor 1