Article
The cystic fibrosis delta F508 gene mutation and cancer.
Human mutation - 1 Jan 1997
Padua R A, Warren N, Grimshaw D, Smith M, Lewis C, Whittaker J, Laidler P, Wright P, Douglas-Jones A, Fenaux P, Sharma A, Horgan K, West R
Abstract excerpt
Following the observation that relatives of cystic fibrosis (CF) patients have an increased mortality due to leukaemia, a study was initiated to determine whether leukaemia patients had an increased prevalence of the delta F508 CF mutation. No increase in carriers were found among leukaemias; how...
Topics
- Alleles
- Breast Neoplasms
- Colonic Neoplasms
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Electrophoresis, Polyacrylamide Gel
- Heterozygote
- Humans
- Leukemia
- Lymphoma
- Melanoma
- Mutation
- Neoplasms
- Polymerase Chain Reaction
- Sequence Deletion