Article
CFTR deltaF508 carrier status, risk of breast cancer before the age of 40 and histological grading in a population-based case-control study.
International journal of cancer - 23 Oct 1998
Southey M C, Batten L, Andersen C R, McCredie M R, Giles G G, Dite G, Hopper J L, Venter D J
Abstract excerpt
There has been recent interest in the risk of various cancers in cystic fibrosis (CF) patients and carriers of cystic fibrosis transmembrane conductance regulator (CFTR) mutations. It has been proposed that a CFTR mutation may protect against breast cancer, based on evidence that elevated extrace...
Topics
- Adenosine Triphosphate
- Adult
- Age Factors
- BRCA2 Protein
- Breast Neoplasms
- Case-Control Studies
- Cystic Fibrosis Transmembrane Conductance Regulator
- Female
- Genes, BRCA1
- Heterozygote
- Humans
- Mutation
- Neoplasm Proteins
- Odds Ratio
- Risk Factors