Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance

Abstract excerpt

OBJECTIVE: Primary glucocorticoid resistance is characterized by decreased sensitivity to cortisol signalling. We have performed genetic analysis of the glucocorticoid receptor (GR) gene in 12 unrelated patients with primary cortisol resistance as defined by a pathological dexamethasone suppression test. METHODS: Exon specific polymerase chain reaction amplification of the GR gene and sequencing of each exon was...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adrenal Hormones and Disorders
• Share to Estrogen and related hormone effects
• Share to Hormonal Regulation and Hypertension