Article
ETS1, NFkappaB and AP1 synergistically transactivate the human GM-CSF promoter.
Oncogene - 12 Jun 1997
Thomas R S, Tymms M J, McKinlay L H, Shannon M F, Seth A, Kola I
Abstract excerpt
Activation of helper T cells results in coordinate expression of a number of cytokines involved in differentiation, proliferation and activation of the haematopoietic system. Granulocyte-macrophage colony stimulating factor (GM-CSF) is one such cytokine, whose increased expression results mostly from increases in transcription. Cis-acting elements with NFkappaB, AP1 and ETS-like binding motifs have been...
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