Article
Induction of differentiation in cultured rat and human podocytes.
Journal of the American Society of Nephrology : JASN - 1 May 1997
Mundel P, Reiser J, Kriz W
Abstract excerpt
Mature podocytes are highly differentiated cells that are unable to divide in vivo. During glomerulogenesis, podocytes develop from simple cuboidal cells into their adult phenotype, which is characterized by a complex pattern of processes. Cultivation of podocytes under standard conditions leads to dedifferentiation, including the loss of processes and of pp44, a marker of differentiated podocytes. In this study,...
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