Article
Genetic testing in presymptomatic diagnosis of multiple endocrine neoplasia.
Hormone research - 1 Jan 1997
Calender A, Giraud S, Schuffenecker I, Lenoir G M, Gaudray P, Courseaux A, Porchet N, Aubert J P, Zhang C X
Abstract excerpt
Multiple endocrine neoplasias (MEN) are familial diseases characterized by endocrine neoplasms and transmitted in an autosomal dominant manner. In MEN type 1, the major lesions affect parathyroid glands, pancreatic islet cells and anterior pituitary. The MEN-1 gene has been mapped to chromosome 11q13 and a set of DNA-polymorphic markers localized close to this region provides a useful tool for presymptomatic...
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