Article
Efficacy of trimethoprim in murine experimental infection with a thymidine kinase-deficient mutant of Escherichia coli.
Antimicrobial agents and chemotherapy - 1 May 1997
Tokunaga T, Oka K, Takemoto A, Ohtsubo Y, Gotoh N, Nishino T
Abstract excerpt
The antimicrobial activity of trimethoprim is antagonized by thymidine in in vitro susceptibility tests. The purpose of this investigation was to determine whether this antagonism also occurred during experimental infection in mice, which have high serum thymidine concentrations. We derived a mutant strain of Escherichia coli, TT-48, incapable of utilizing exogenous thymidine from parent strain E. coli KC-14 and...
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