Article
Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 1997
Mannucci P M, Mari D, Merati G, Peyvandi F, Tagliabue L, Sacchi E, Taioli E, Sansoni P, Bertolini S, Franceschi C
Abstract excerpt
Gene polymorphisms associated with the plasma levels of fibrinogen, factor VII, and plasminogen activator inhibitor 1 (PAI-1)-hemostasis proteins that help to predict the risk of atherothrombotic disease-were compared in 124 healthy individuals > or = 100 years old and 130 young, healthy individuals to identify genetic influences on extreme longevity. We investigated the restriction fragment length polymorphism...
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