Analysis of helicase gene mutations in Japanese Werner's syndrome patients.

doi:10.1007/s004390050336

Article

Analysis of helicase gene mutations in Japanese Werner's syndrome patients.

Human genetics - 1 Feb 1997

Goto M, Imamura O, Kuromitsu J, Matsumoto T, Yamabe Y, Tokutake Y, Suzuki N, Mason B, Drayna D, Sugawara M, Sugimoto M, Furuichi Y

Abstract excerpt

The profile of helicase gene mutations was studied in 89 Japanese Werner's syndrome (WRN) patients by examining the previously described mutations 1-4 as well as a new mutation found during this study, designated mutation 5. Of 178 chromosomes (89 patients), 89 chromosomes (50%) had mutation 4, 1...

Topics

DNA Helicases
DNA Mutational Analysis
Female
Genetic Markers
Genotype
Humans
Japan
Male
Mutation
Pedigree
Werner Syndrome

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