Article
Identification of cell adhesive active sites in the N-terminal domain of thrombospondin-1.
The Biochemical journal - 1 Feb 1997
Clezardin P, Lawler J, Amiral J, Quentin G, Delmas P
Abstract excerpt
Using a series of fusion proteins that span almost all of the thrombospondin-1 (TSP-1) molecule, we observed in this study that Chinese hamster ovary (CHO) K1 cells strongly attached to the N-terminus but not to the other domains of TSP-1 (e.g. the C-terminus, and type 1, type 2 and type 3 repeat...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Blood Platelets
- CHO Cells
- Cell Adhesion
- Chromatography, Affinity
- Cricetinae
- Glycosaminoglycans
- Humans
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Protein Binding
- Recombinant Fusion Proteins
- Sequence Alignment
- Thrombospondins