Article
Strain variability among Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genomes: evidence that a large cohort of United States AIDS patients may have been infected by a single common isolate.
Journal of virology - 1 Mar 1997
Zong J C, Metroka C, Reitz M S, Nicholas J, Hayward G S
Abstract excerpt
Previous analysis of the majority of Kaposi's sarcoma (KS) tumors, in both AIDS and non-AIDS populations, has revealed the consistent presence of two small subsegments (open reading frame 25/26 [ORF25/26] and ORF75) of a novel human gamma class herpesvirus genome referred to as KSHV or HHV-8. We have carried out DNA sequence comparisons with DNAs encompassing a total of 2,500 bp each over three separate...
Topics
- AIDS-Related Opportunistic Infections
- Acquired Immunodeficiency Syndrome
- Base Sequence
- Cohort Studies
- DNA, Viral
- Gammaherpesvirinae
- Genetic Variation
- Genome, Viral
- Herpesvirus 4, Human
- Herpesvirus 8, Human
- Humans
- Molecular Sequence Data