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Article

The transneuronal spread phenotype of herpes simplex virus type 1 infection of the mouse hind footpad.

Journal of virology - 1 Mar 1997

Engel J P, Madigan T C, Peterson G M

Abstract excerpt

The mouse hind footpad inoculation model has served as a standard laboratory system for the study of the neuropathogenesis of herpes simplex virus type 1 (HSV-1) infection. The temporal and spatial distribution of viral antigen, known as the transneuronal spread phenotype, has not previously been described; nor is it understood why mice develop paralysis in an infection that involves sensory nerves. The...

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Identifiers

PMID: 9032380
DOI: 10.1128/JVI.71.3.2425-2435.1997
PMCID: PMC191353

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Source receipt: pubmed, retrieved 7 Sept 2026.

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