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Hepatocyte nuclear factor-4 alpha gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients.

Research communications in molecular pathology and pharmacology - 1 Dec 1996

Nakajima H, Yoshiuchi I, Hamaguchi T, Tomita K, Yamasaki T, Iizuka K, Okita K, Moriwaki M, Ono A, Oue T, Horikawa Y, Shingu R, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y

Abstract excerpt

A mutation in the hepatocyte nuclear factor-4 alpha (HNF-4 alpha) gene has been recently reported to cause maturity-onset diabetes of the young (MODY) (Yamagata, Furuta, et al., 1996). The mutation can also be a good candidate for the responsible gene of non-insulin dependent diabetes mellitus (NIDDM). The existence of the mutated allele of Q268X (C to T substitution within the exon 7 of HNF-4 alpha gene) was...

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PMID: 9029679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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