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Article

Two amino acid changes at the N-terminus of transmissible gastroenteritis coronavirus spike protein result in the loss of enteric tropism.

Virology - 20 Jan 1997

Ballesteros M L, Sánchez C M, Enjuanes L

Abstract excerpt

To study the molecular basis of TGEV tropism, a collection of recombinants between the PUR46-MAD strain of transmissible gastroenteritis coronavirus (TGEV) infecting the enteric and respiratory tracts and the PTV strain, which only infects the respiratory tract, was generated. The recombinant isolation frequency was about 10(-9) recombinants per nucleotide and was 3.7-fold higher at the 5'-end of the S gene than...

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Identifiers

PMID: 9018137
DOI: 10.1006/viro.1996.8344
PMCID: PMC7130969

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