Article
Two amino acid changes at the N-terminus of transmissible gastroenteritis coronavirus spike protein result in the loss of enteric tropism.
Virology - 20 Jan 1997
Ballesteros M L, Sánchez C M, Enjuanes L
Abstract excerpt
To study the molecular basis of TGEV tropism, a collection of recombinants between the PUR46-MAD strain of transmissible gastroenteritis coronavirus (TGEV) infecting the enteric and respiratory tracts and the PTV strain, which only infects the respiratory tract, was generated. The recombinant iso...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Viral
- Cells, Cultured
- Cloning, Molecular
- Crossing Over, Genetic
- Floxuridine
- Genome, Viral
- Genotype
- Ileum
- Intestine, Small
- Jejunum
- Lung
- Male
- Mutagenesis
- Neutralization Tests
- Point Mutation
- RNA, Viral