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Article

Evidence for UV-associated activation of telomerase in human skin.

Cancer research - 1 Feb 1997

Ueda M, Ouhtit A, Bito T, Nakazawa K, Lübbe J, Ichihashi M, Yamasaki H, Nakazawa H

Abstract excerpt

Telomerase activation plays a crucial role in the immortalization of human cells and carcinogenesis; however, the temporal and pathophysiological aspects of the activation in vivo are poorly understood. We found telomerase activity not only in malignant tumors (91%) but also in most benign (60%)...

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Source

Identifiers

PMID: 9012457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9012457-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Evidence for UV-associated activation of telomerase in human skin.PMID 9012457Read ↗

Telomerase activity in melanoma and non-melanoma skin cancerSemantic proximity Read ↗

Detection of Telomerase Activity in Malignant and Nonmalignant Skin ConditionsSemantic proximity Read ↗

Correlation of the expression of human telomerase subunits with telomerase activity in normal skin and skin tumorsSemantic proximity Read ↗

The role of telomeres in the ageing of human skinSemantic proximity Read ↗

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes.Semantic proximity Read ↗

Skin Aging: A Role for Telomerase and Telomere Dynamics?Semantic proximity Read ↗

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas.Semantic proximity Read ↗

Impairment of the telomere/telomerase system and genomic instability are associated with keratinocyte immortalization induced by the skin human papillomavirus type 38Semantic proximity Read ↗

Tissue context-activated telomerase in human epidermis correlates with little age-dependent telomere lossSemantic proximity Read ↗

Molecular alterations in human skin tumors.Semantic proximity Read ↗

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytesSemantic proximity Read ↗

Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.Semantic proximity Read ↗

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