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Article

Identification of the gene family encoding the 160-kilodalton Trypanosoma cruzi complement regulatory protein

1 Feb 1997

Abstract excerpt

Trypanosoma cruzi trypomastigotes are exquisitely resistant to the lytic effects of vertebrate complement, and this characteristic contributes to the survival of the parasites in the host bloodstream. Trypomastigotes avoid complement-mediated lysis by the production of a surface glycoprotein that inhibits the formation of the alternative and classical C3 convertase, thus preventing activation and amplification of...

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PMID: 9009282
DOI: 10.1128/iai.65.2.349-357.1997

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