Article
In vivo spontaneous neuronal to neuroendocrine lineage conversion in a subset of neuroblastomas.
The American journal of pathology - 1 Jan 1997
Gestblom C, Hoehner J C, Hedborg F, Sandstedt B, Påhlman S
Abstract excerpt
Neuroblastoma is an embryonal tumor derived from the sympathetic nervous system. Although all neuroblastomas have a neuronal character, a subset of tumors also show evidence of extra-adrenal neuroendocrine differentiation in discrete cell layers. A characterization of the cells of the developing human sympathetic nervous system was performed, identifying growth-associated protein-43, neuropeptide tyrosine, and...
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