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Construction of a genome-length cDNA clone for human astrovirus serotype 1 and synthesis of infectious RNA transcripts

1 Feb 1997

Abstract excerpt

We have constructed a genome-length cDNA clone for human astrovirus serotype 1. When a human colon cancer-derived cell line, CaCo-2, is transfected with RNA transcribed in vitro from this cDNA clone, infectious virus is produced at titers close to those observed after infection with intact astrovirus. A rodent cell line, BHK, which is largely refractory to astrovirus infection, was found to support efficient...

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PMID: 8995706
DOI: 10.1128/jvi.71.2.1713-1717.1997

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