Article
Mutation rate varies among alleles at a microsatellite locus: phylogenetic evidence.
Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 1996
Jin L, Macaubas C, Hallmayer J, Kimura A, Mignot E
Abstract excerpt
The understanding of the mutational mechanism that generates high levels of variation at microsatellite loci lags far behind the application of these genetic markers. A phylogenetic approach was developed to study the pattern and rate of mutations at a dinucleotide microsatellite locus tightly linked to HLA-DQB1 (DQCAR). A random Japanese population (n = 129) and a collection of multiethnic samples (n = 941) were...
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