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Article

Antigenicity, pathogenicity, and immunogenicity of small and large plaque infectious bursal disease virus clones.

Avian diseases - 1 Jan 2000

Hassan M K, Nielsen C K, Ward L A, Jackwood D J, Saif Y M

Abstract excerpt

A serotype 1 variant strain of infectious bursal disease virus designated IN was passaged 40 times in BGM-70 cell line. A small plaque (SP) clone and a large plaque (LP) clone were then isolated and plaque purified four times. The SP and LP viruses formed circular plaques about 0.5 mm and 6.0 mm in diameter, respectively. Both clones lost their pathogenicity for specific-pathogen-free (SPF) chickens and did not...

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PMID: 8980814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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