Article
Hypophosphatasia: levels of bone alkaline phosphatase immunoreactivity in serum reflect disease severity.
The Journal of clinical endocrinology and metabolism - 1 Jun 1996
Whyte M P, Walkenhorst D A, Fedde K N, Henthorn P S, Hill C S
Abstract excerpt
Hypophosphatasia is a rare metabolic bone disease characterized biochemically by deficient enzymatic activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). All isoforms of TNSALP (e.g. bone and liver TNSALP), apparently differing only by posttranslational modifications, ar...
Topics
- Adult
- Alkaline Phosphatase
- Antibodies, Monoclonal
- Bile Duct Diseases
- Bone Diseases
- Bone and Bones
- Child, Preschool
- Humans
- Immunoradiometric Assay
- Isoenzymes
- Liver Diseases
- Mutation
- Reference Values
- Severity of Illness Index