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Article

Hypophosphatasia: levels of bone alkaline phosphatase immunoreactivity in serum reflect disease severity.

The Journal of clinical endocrinology and metabolism - 1 Jun 1996

Whyte M P, Walkenhorst D A, Fedde K N, Henthorn P S, Hill C S

Abstract excerpt

Hypophosphatasia is a rare metabolic bone disease characterized biochemically by deficient enzymatic activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). All isoforms of TNSALP (e.g. bone and liver TNSALP), apparently differing only by posttranslational modifications, are affected. To explore the biochemical basis and extremely variable severity of hypophosphatasia, we used 2-site...

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Identifiers

PMID: 8964842
DOI: 10.1210/jcem.81.6.8964842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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