Article
A gene for hereditary pancreatitis maps to chromosome 7q35.
Gastroenterology - 1 Jun 1996
Whitcomb D C, Preston R A, Aston C E, Sossenheimer M J, Barua P S, Zhang Y, Wong-Chong A, White G J, Wood P G, Gates L K, Ulrich C, Martin S P, Post J C, Ehrlich G D
Abstract excerpt
BACKGROUND & AIMS: Hereditary pancreatitis (HP) is an autosomal-dominant disorder with incomplete penetrance characterized by recurrent bouts of severe epigastric pain with onset usually at 5-10 years of age. A genetic linkage study was designed to identify the HP gene. METHODS: A 500-member pedigree was constructed from a U.S. kindred centered in eastern Kentucky and western Virginia. A genome-wide search...
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