Article
Mutation selection and tumour progression.
Medical hypotheses - 1 Jan 2000
Wheldon T E
Abstract excerpt
It is proposed that tumour progression results from the increased mutability of tumour cells and that this mutability leads to the acquisition of a large number of 'neutral' mutations having no significant effects under physiological conditions but capable of lethal expression under different conditions. High temperatures often lead to expression of neutral mutations and this could provide a mechanism for the...
Topics
- Hot Temperature
- Humans
- Models, Biological
- Mutation
- Neoplasm Proteins
- Neoplasms
- Neoplasms, Experimental
- Protein Denaturation
- Selection, Genetic