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Article

Familial transmission of the FMR1 CGG repeat.

American journal of human genetics - 1 Dec 1996

Nolin S L, Lewis F A, Ye L L, Houck G E, Glicksman A E, Limprasert P, Li S Y, Zhong N, Ashley A E, Feingold E, Sherman S L, Brown W T

Abstract excerpt

To better define the nature of FMR1 CGG-repeat expansions, changes in allele sizes for 191 families with fragile X and for 33 families with gray-zone repeats (40-60) were analyzed. Expansion of the fragile X chromosome to the full mutation was seen in 13.4% of offspring from premutation mothers w...

Topics

Alleles
Analysis of Variance
Chromosome Fragility
Female
Fragile X Syndrome
Humans
Male
Pedigree
Polymerase Chain Reaction
Trinucleotide Repeats

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 8940270
PMCID: PMC1914886

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8940270-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Familial transmission of the FMR1 CGG repeat.PMID 8940270Read ↗

Expansion of the fragile X CGG repeat in females with premutation or intermediate alleles.Semantic proximity Read ↗

Expansion of an FMR1 grey-zone allele to a full mutation in two generations.Semantic proximity Read ↗

Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles.Semantic proximity Read ↗

Fragile X full mutation expansions are inhibited by one or more AGG interruptions in premutation carriers.Semantic proximity Read ↗

Apparent regression of the CGG repeat in FMR1 to an allele of normal size.Semantic proximity Read ↗

Fragile X "gray zone" alleles: AGG patterns, expansion risks, and associated haplotypes.Semantic proximity Read ↗

Genetic variation and intergenerational FMR1 CGG-repeat stability in 100 unrelated three-generation families from the normal population.Semantic proximity Read ↗

Expansion to full mutation of a FMR1 intermediate allele over two generations.Semantic proximity Read ↗

Mechanisms of the FMR1 Repeat Instability: How Does the CGG Sequence Expand?Semantic proximity Read ↗

AGG interruptions within the maternal FMR1 gene reduce the risk of offspring with fragile X syndrome.Semantic proximity Read ↗

Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox.Semantic proximity Read ↗

Analysis of a CGG sequence at the FMR-1 locus in fragile X families and in the general population.Semantic proximity Read ↗

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