Contamination of Commercially Available Fetal Bovine Sera with Bovine Viral Diarrhea Virus Genomes: Implications for the Study of Hepatitis C Virus in Cell Cultures

Abstract excerpt

The establishment of cell cultures for hepatitis C virus (HCV) is important for its study as a human pathogen. However, in reported cell lines, HCV demonstrates low levels of replication detected primarily by reverse transcription-polymerase chain reaction (RT-PCR) assays. In attempts to culture HCV, an additional complication was observed. From mock-infected cultures, cDNA of appropriate size was obtained by...

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