Article
Bilineal transmission and phenotypic variation of Tourette's disorder in a large pedigree.
Journal of the American Academy of Child and Adolescent Psychiatry - 1 May 1996
McMahon W M, van de Wetering B J, Filloux F, Betit K, Coon H, Leppert M
Abstract excerpt
OBJECTIVE: Variability in the clinical phenotype of Tourette's disorder (TD) was assessed in a single large family, with a focus on the influence of bilineal transmission. METHOD: Tics, obsessive-compulsive symptoms, and attention-deficit symptoms were evaluated through interview and standardized checklists for 175 descendants and 16 spouses who married into a single four-generation pedigree. RESULTS: Some form...
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